When it is exposed to tumor-related active mediators like transforming growth factor β (TGF-β), platelet derived growth factor (PDGF), and fibroblast growth factor (FGF), which are normally present in a dormant state, it enters an activated state and differentiates into a class of fibroblasts with properties similar to myofibroblasts. Here, TGFB1 is linked to neoplasm.