This identified four DMRs for PM2.5 in or near to SDHAP3, ZFP57, HOXA5, and PRM1, and two DMRs for NOX also at SDHAP3 and ZFP57. The HOXA5 DMR was associated with monocyte expression of HOXA5, HOXA9, and HOXA10. These epigenetic changes may be insightful as to how air pollution contributes to cardiovascular disease risk. The gene discussed is HOXA5; the disease is cardiovascular disorder.