Notably, the strongest genetic association emerges from the MHCII region on chromosome 6, accounting for 30–50% of the total genetic risk of RA.[1, 3, 4] Within the MHCII region, haplotypes containing HLA‐DRB1 alleles are associated with RA, including *04:01, *04:04, *04:05, *04:08, *01:01, *01:02, *14:02, and *10:01 alleles. This evidence concerns the gene HLA-DRB1 and rheumatoid arthritis.