In contrast, pTDP‐43 inclusion was absent in the ALS patient with FUS mutation (Figure S2), consistent with previous report in autopsy spinal cord specimens from nine ALS patients with FUS mutations by Nolan et al. [26] These findings indicate that pTDP‐43 has different roles in the pathogenesis of ALS with different disease‐causing gene mutations. This evidence concerns the gene FUS and amyotrophic lateral sclerosis.