Trist et al. [24] found co‐deposition of SOD1, TDP‐43, and p62 proteinopathies in spinal cord motor neurons from SOD1‐ALS patients, while no cytoplasmic TDP‐43 immunoreactivity was observed in the prior study by Tan et al. [25] To confirm our findings in SOD1‐ALS patients, we invited an independent lab from us to repeat the immunostaining assay and obtained similar results (Figure S5). Here, TARDBP is linked to amyotrophic lateral sclerosis.