The core pathological characteristics of ALS include abnormal protein deposits in motor neurons and glial cells [7], and diverse aggregation‐prone proteins have been previously identified, including TAR DNA‐binding protein 43 kDA (TDP‐43), fused‐in‐sarcoma protein (FUS), superoxide dismutase 1 (SOD1), Optineurin (OPTN), Ubiquilin‐2 (UBQLN2), Ataxin‐2 (ATXN2), and p62 [8]. The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.