Besides, the downregulation of miR‐5590‐3p reversed the suppressive effect of silencing MIR100HG on lung cancer cell proliferation and metastasis, and the overexpression of DCBLD2 also reversed the effect of overexpression of miR‐5590‐3p on lung cancer cell proliferation and metastasis. Here, DCBLD2 is linked to lung carcinoma.