Notably, depleting VEGF in fibroblasts phenocopied the effects of USP7 inhibition on spheroid growth in the tri‐cultures, and there was no additional effect of inhibiting USP7 in VEGF‐depleted fibroblast tri‐cultures, demonstrating the key role of fibroblast‐secreted VEGF in determining the response of tumour spheroids to USP7. The gene discussed is USP7; the disease is neoplasm.