Previous findings in cancer cells have indicated that hypoxia‐induced K63‐polyubiquitinated USP7 deubiquitinates HIF‐1α causing CBP‐mediated H3K56 acetylation on the gene promoter of HIF‐1α to advance epithelial‐to‐mesenchymal transition and metastasis.53 Here, HIF1A is linked to cancer.