Previous studies have linked DNMT1 and UHRF1 to the modulation of VEGF signalling, but only in cancer cells.  Overall, these results suggest that USP7‐dependent, UHRF1‐mediated epigenetic regulation of the VEGFA locus is necessary to enable efficient recruitment of HIF‐1α and p53 to drive transcription in hypoxic fibroblasts. Here, DNMT1 is linked to cancer.