The changes in the leptin correlations were more evident and consistent in subgroups of RA patients than in the controls, where a significantly positive correlation of leptin/BMI with muscle was seen in only the RA patients (Figure 3A–D) while negative correlations of adiponectin normalized to BMI and BFM with muscle were also found in only the RA patients (Figure 3E–H). This evidence concerns the gene LEP and rheumatoid arthritis.