AGT and primary hyperoxaluria type 1: PH1 (OMIM259900), the most frequent and severe form, is caused by the deficit of alanine:glyoxylate aminotransferase (AGT), a Vitamin B6-dependent peroxisomal enzyme that catalyzes a transaminase reaction converting l-alanine and glyoxylate to pyruvate and glycine, respectively [9,10].