Increased levels of Leukemia inhibitory factor receptor were associated with a decreased risk of ALS (OR = 0.903, PIVW = 0.017), with no significant heterogeneity (MR Egger Q = 2.064, Q p-value = 0.151) or horizontal pleiotropy (P Egger Intercept = 0.913) observed (Figure 2) (Supplementary Tables S2, S3, S8). This evidence concerns the gene LIFR and amyotrophic lateral sclerosis.