Accordingly, an AAV9 coding for the SNCA gene with the A53T mutation under the control of human synapsin promoter [(synapsin)AAV9-SynA53T] was chosen for intraparenchymal deliveries into the left putamen in two cynomolgus macaques (Macaca fascicularis) to induce a retrograde transduction of brain areas innervating the putamen in an attempt to generate a widespread synucleinopathy throughout cortical and subcortical brain areas. This evidence concerns the gene SNCA and synucleinopathy.