TH and synucleinopathy: For any study intended to induce a widespread synucleinopathy in NHPs, additional attention should be placed in analyzing the potential impact of α-Syn expression within nigrostriatal projections, both at origin (e.g., number of TH+ neurons in the substantia nigra pars compacta) as well at destination (e.g., density of TH+ terminals in the putamen).