Concerning daily insulin dose (IU), there was also a significant difference between the NG and the pDM groups (25.5 [12.4] vs 35.7 [25.1]; P ≤ .001) and between the pDM and the T2DM groups (35.7 [25.1] vs 60.6 [23.9]; P = .004). The gene discussed is INS; the disease is type 2 diabetes mellitus.