PIK3CA and breast cancer: On the other hand, the suppression of FAM83B following the activation of the PI3K/AKT/mTOR pathway led to a decrease in autophagy in EC cells, yet enhanced the growth, movement, and invasive capabilities of cancer cells (76).In breast cancer cell lines, elevated expression of FAM83B activates the PI3K/AKT signaling pathway (77) and stimulates mTOR activation (78).