found that inhibiting autophagy with chloroquine and bafilomycin A1 and silencing the autophagy-regulating gene ATG5 did not sensitize Fulvestrant + Palbociclib to breast tumor cells, indicating that in breast tumors, the autophagy mechanism is non-protective under the action of Fulvestrant + Palbociclib (41). Here, ATG5 is linked to breast neoplasm.