L. plantarum hydroxy fatty acids reduce SREBP-1c mRNA expression and LXRα activation, which is the proposed mechanism by which L. plantarum suppresses lipogenesis and triacylglycerol accumulation in HepG2 liver cancer cells that express low levels of PPARα (Nanthirudjanar et al., 2015). The gene discussed is PPARA; the disease is liver cancer.