According to Table 1 which indicates the missense or nonsynonymous variants, 29 genes can be prioritized including ABCA1, ABCB1, ACE, AGT, ALDH2, APOB, APOC1, APOE, CES1, CYP2B6, CYP2C9, EDN1, F7, FABP1, FMO3, ITGB3, KDR, LEPR, NOS3, NPPA, NR3C2, NT5C2, P2RY12, PON1, PTGS1, SCARB1, SH2B3, SLCO1B1, and TLR4. These genes can be considered for WES analysis for CAD patients or detecting CAD risk in healthy individuals as prognostic data. The gene discussed is SH2B3; the disease is coronary artery disorder.