Previous studies have shown that neutrophils, one of the first leukocytes activated after Kupffer cell recruitment in NAFLD, can secrete large amounts of quantities of IL-6 and proteases, including myeloperoxidase, neutrophil elastase, and protease 3, enhancing the inflammatory environment, promoting ROS, and causing hepatocyte damage, thus contributing to the progression of NASLD[[60], [61], [62], [63], [64]]. Here, ELANE is linked to metabolic dysfunction-associated steatotic liver disease.