Gpx4−/− mice exhibit complete penetrant embryonic lethality (Imai et al., 2003; Yant et al., 2003), and conditional knockout of Gpx4 is associated with cancer, neurodegenerative diseases, acute kidney injury or liver injury, which can be prevented or mitigated by inhibiting ferroptosis (Imai et al., 2003; Seiler et al., 2008; Carlson et al., 2016; Doll et al., 2017; Hambright et al., 2017). Here, GPX4 is linked to cancer.