GPX4 and acute kidney injury: Deficiency of the key endogenous inhibitor of ferroptosis, glutathione peroxidase 4 (GPX4), would lead to AKI in mice, while ferrostatin-1 (Fer-1), an inhibitor of ferroptosis, attenuates renal injury by scavenging lipid peroxidation in vivo (Friedmann et al., 2014).