Xu et al. found that α-Asarone has a significant protective effect against cerebral ischemia/reperfusion injury, mainly by regulating ROS activity, inhibiting NF-κB phosphorylation, reducing the excessive activation of NLRP3 inflammasomes, and exerting anti-inflammatory effects to protect against cerebral ischemia/reperfusion injury (Fei-Fei et al., 2022). Here, NFKB1 is linked to brain ischemia.