Sun et al. identified the role of the low-density lipoprotein receptor (LDLR) in mediating NLRP3-dependent neuronal pyroptosis and neuroinflammation after ischemic stroke, suggesting LDLR as a potential therapeutic target for neuroinflammatory responses in acute cerebral ischemic injury (Sun et al., 2020). Here, NLRP3 is linked to ischemic stroke.