NLRP3 and brain ischemia: Li et al. found that indobufen or aspirin pretreatment combined with clopidogrel or ticagrelor can reduce rat cerebral ischemia-reperfusion and PC12 cell oxygen glucose deprivation/reoxygenation inflammatory corpuscle mediated pyroptosis by inhibiting the NF-κB/NLRP3 signaling pathway (Li F. et al., 2021b).