NOS3 and ischemia: Lower eNOS-derived NO (lower nitrate, nitrite, and NOx concentration and eNOS expression) before ischemia (Chou et al., 2010; Yousefzadeh and Jeddi, 2023) and higher iNOS-derived NO (higher nitrate, nitrite, and NOx concentration and higher iNOS expression) during IR (Sakanashi et al., 2013; Yousefzadeh and Jeddi, 2023) in the heart tissue have been reported in OVX rats.