HMGCR and acute coronary syndrome: Initially, we conducted comprehensive searches across online databases, including MEDLINE/ PubMed, EMBASE, and the Web of Science Search terms encompassed combinations of relevant PubMed MeSH terms and associated text terms such as statins, hydroxymethylglutaryl-CoA reductase inhibitors, 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, ezetimibe, and acute coronary syndrome.