APOE and Alzheimer disease: When both scores are directly compared, LR performs equal to or better than RLS for correlations with memory tests (3, 17, 18, 22, 23), diagnostic discrimination (3, 18, 23), as well as other known risk factors for AD, including hippocampal volume, AD-specific biomarkers, and apolipoprotein E (APOE)ε4 status (22–24).