Transcript abundance for both Ramp1 and Grin1, which encodes an NMDA receptor subunit, were more abundant in the colon after SCI. Taken together with the known role of NO in ENS inhibition, we hypothesize that CGRP plays a central role in the pathogenesis of both NB-associated abdominal pain and colonic dysmotility. The gene discussed is RAMP1; the disease is neuroblastoma.