GPX4 and Sepsis: Transcription factors such as forkhead box O3 and nuclear factor kappa B required for muscle atrophy are activated during sepsis, and these transcription factors inhibit SLC7A11 expression (Zhong et al., 2023; Wu et al., 2024) which causes the inhibition of the SXc−-GSH-GPX4 signaling pathway (Wang et al., 2022; Zhang et al., 2022).