Among them, bacteria such as Bacteroides and Erysipelothrichaceae can significantly increase the production of short chain fatty acids, Harmful bacterial species such as Rikenellaceae and Desulfovibrionaceae have significantly decreased; SZ-A can regulate the insulin secretion of KKAy mice indirectly or directly by regulating the intestinal microenvironment to achieve its anti DM effect. Here, INS is linked to diabetes mellitus.