Logistic regression analysis adjusted for age, sex, and comorbidities (hypertension, type 2 diabetes, and obesity) revealed a statistically significant association between the TMPRSS2 rs2070788 and rs75603675 genetic variants and between the SERPINE1 rs2227631, rs222667 and rs2227692 and critical and deceased outcomes. This evidence concerns the gene SERPINE1 and hypertensive disorder.