Logistic regression analysis adjusted for age, sex, and comorbidities (hypertension, type 2 diabetes, and obesity) revealed a statistically significant association between the TMPRSS2 rs2070788 and rs75603675 genetic variants and between the SERPINE1 rs2227631, rs222667 and rs2227692 and critical and deceased outcomes. The gene discussed is TMPRSS2; the disease is hypertensive disorder.