OPTN and amyotrophic lateral sclerosis: The accumulation of impaired mitochondria is regarded as a catalyst for ALS, and concomitantly, deficiencies in mitophagy are also evident in ALS models (20).To date, various genes associated with ALS have been identified to participate in the degradation of damaged mitochondria through the process of mitophagy, such as p62, OPTN, and TBK1 as discussed previously (21, 22).