According to it, four of eighteen genes (BCKDHA, JTB, KYNU, GTF2H5) have good diagnostic value in the diagnosis of ALS with AUC>0.6 in both the GSE112676 and GSE112680 dataset (Figures 7A, B), suggesting that these four genes not only have the prognostic effect but also have the potential diagnostic value. The gene discussed is KYNU; the disease is amyotrophic lateral sclerosis.