Branched Chain Keto Acid Dehydrogenase E1 Subunit Alpha (BCKDHA), Jumping Translocation Breakpoint (JTB), KYNU, and General Transcription Factor IIH Subunit 5 (GTF2H5) (Figures 7C, D) exhibited notable variations in both peripheral blood of ALS patients and the lumbar spinal cord of SOD1G93A mice. Here, BCKDHA is linked to amyotrophic lateral sclerosis.