According to the 2016 revision of the World Health Organization (WHO) classification of lymphoid neoplasms, TFH-originated nodal peripheral T-cell lymphomas (nPTCLs) were classified based on the expression of at least two or three TFH markers, such as CD279/PD1, CD10, BCL-6, CXCL13, and ICOS. The gene discussed is PDCD1; the disease is lymphoid neoplasm.