ADIPOQ and ischemia: Both etanercept and exogenous adiponectin supplementation (3 days post-trauma or 10 min before reperfusion) markedly inhibited oxidative/nitrative stress and ischemia/reperfusion injury in WT mice, whereas adiponectin supplementation substantially attenuated post-traumatic ischemia/reperfusion injury in adiponectin-knockout mice (26).