CD40LG and infection: Our data demonstrating that loss of TET2 increased B-1 cell subset numbers in antibody-producing niches and reduced CDR3 diversity suggests that TET2 may regulate the pool of antigen-specific IgM produced by B-1 cells (Figure 8) and underscores the need for further study of the impact and mechanisms whereby TET2 regulates B-1 cells, especially in the context of infection and diseases involving chronic inflammation.