Interestingly, significant enrichment in neurotransmitter and synapse-related pathways was seen in both B-1a and B-1b cells from the TET2-KO animals compared to the control animals (Supplementary Figure 3B, These GSEA results provide potential avenues for further hypothesis-driven studies of the role of TET2 in sensory-neural control of B cells, an emerging area of potential significance, recently also connected to cardiovascular disease development via other immune cells (57–59). This evidence concerns the gene TET2 and cardiovascular disorder.