TET2 and myelodysplastic syndrome: Given their self-renewal capacity, we hypothesized that B-1 cells may be regulated by TET2, an epigenetic modulator that has been implicated in the clonal expansion of hematopoietic cells leading to disorders such as myelodysplastic syndromes (MDS) (30–34) and acute myeloid leukemia (AML) (27–30).