Thus, according to several studies, including meta-analyses, there are signs of increased activation of systemic inflammation among patients with schizophrenia, including elevated levels of the proinflammatory cytokines, including interleukin-1β (IL-1β), IL-8 and IL-6 in both blood serum and cerebrospinal fluid [5-9]. The gene discussed is CXCL8; the disease is schizophrenia.