Fetal-specific genes (HMGA2) have been identified in a rare HSC-like fraction of KMT2A-r infant leukemia (Chen et al., 2022), and IGF2BP1 maintains LSC by regulating HOXB4, MYB, and ALDH1A1 in pediatric leukemia cell lines (Elcheva et al., 2020). Here, IGF2BP1 is linked to leukemia.