The delayed rectifiers Kv2.1 and Kv2.2 (encoded by Kcnb1 and Kcnb2) had multiple down-regulated phosphorylation sites (Figure 3M) and two sites were decreased for epilepsy-associated Kv2.1 (encoded by Kcnb1) (Figure 3M). The gene discussed is KCNB1; the disease is epilepsy.