We established an in situ xenograft glioma mouse model by transplanting TBD0220 cells into 5‐week‐old female BALB/c nude mice (Figure 6A), which were divided into a control group and an ARID1A KD group, and underwent gavage treatment with TMZ after randomization to a randomized group on day 7 postoperatively to mimic the process of chemotherapy in clinical patients, respectively. This evidence concerns the gene ARID1A and central nervous system cancer.