We identified the top 15 disease‐causing mutations with the highest mutation rates in the entire glioma patient cohort, including MUC16, ZFHX3, RNF214, FAT4, EP400, SMG1, BPTF, CHD9, MYH11, SPEN, SRCAP, MDC1, ARID1A, and BRD4 (Figure 1C). This evidence concerns the gene SPEN and central nervous system cancer.