Along with our demonstration of the causal role that MMP‐9‐dependent H3NT proteolysis plays in activating a cluster of growth‐stimulatory gene in colon cancer cells, our ChIPac‐qPCR analysis indicated that H3NT proteolysis in the promoter region of target genes correlates with MMP‐9 transactivation. Here, MMP9 is linked to colonic neoplasm.