Adding support to these observations and in accordance with the concept of MMP‐9‐H3 interaction as an important process for MMP‐9‐dependent H3NT proteolysis, our immunoprecipitation of endogenous MMP‐9 also showed a stable association of histone H3 in colon cancer cells (Fig. S3). This evidence concerns the gene MMP9 and malignant colon neoplasm.