Next, we explore the determined which m6A demethylase regulates m6A modification during ferroptotic death, and found that m6A modification levels were still increased in knockdown ALKBH5 cells treated with Erastin or RSL3, however, the increased m6A modification levels in CRC cells treated with Erastin or RSL3 were blocked with the knockdown of FTO (Fig. 2e, f and S2i, l). Here, FTO is linked to colorectal carcinoma.