As the expression of METTL3, METTL14, and ALKBH5 were decreased under Erastin or RSL3 treatment mediated by FTO, we also examined the response of knockdown METTL3, METTL14, and ALKBH5 to Erastin or RSL3 treatment in CRC cells. Here, METTL14 is linked to colorectal carcinoma.