Furthermore, we found that knockdown of FTO decreased the levels of ALKBH5, METTL3, and METTL14 (Fig. S2m), which explained the decreased levels of ALKBH5, METTL3, METTL14, and WTAP were mediated by FTO during the CRC cells ferroptotic death. This evidence concerns the gene ALKBH5 and colorectal carcinoma.