However, we found that the protein levels of FTO, ALKBH5, METTL3, METTL14, WTAP, and YTHDF2 were all decreased in CRC cells by treating with either Erastin or RSL3 in a dose dependent manner (Fig. 2a, b and S2c, d). This evidence concerns the gene YTHDF2 and colorectal carcinoma.