FTO and neoplasm: We first examined the effect of FTO on tumor growth, then, we established a patient-derived xenograft (PDX) model, and found that knockdown FTO significantly decreased the tumor growth (Fig. S3h, i), tumor masses (Fig. S3j), and Ki67 expression, as well as with the increased ferroptosis biomarker 4-hydroxynonenal (4HNE) levels (Fig. S3k).