With specific regard to the ME/CFS cohort, our results revealed higher levels of both pro-inflammatory (IL1-β, IL-6, TNF-α, and IP-10) and anti-inflammatory cytokines (IL-4, IL-10), as compared with matched sedentary healthy controls, indicating an imbalanced cytokine profile and disturbed immune system. Here, TNF is linked to myalgic encephalomeyelitis/chronic fatigue syndrome.