When the expression of these enzymes was altered by xenobiotics like nanoparticles, several health problems occurred, including brain disorders due to SMS deficiency [32], apoptosis and inflammation due to dysregulated ACOT2 and BAAT [33, 34], neurological diseases and neuroinflammation induced by overexpression of GLS and GS [35, 36]. The gene discussed is ACOT2; the disease is brain disorder.