<h4>Background</h4>While coronary artery calcification (CAC) is recognized as a reliable marker for coronary atherosclerosis, the relationship between the concentration of C-reactive protein (CRP) and the incidence and progression of CAC remains controversial.<h4>Method</h4>PubMed, Embase, Web of Science, and Scopus were systematically searched to identify relevant observational studies until October 2023. Here, CRP is linked to coronary artery calcification.