The discovery, as well as clarification of the physiological roles, of CGRP and other relevant neurotransmitters (such as pituitary adenylate cyclase-activating polypeptide (PACAP), glyceryl trinitrate (producing nitric oxide), etc.)[58, 59, 69–74] allowed researchers to correlate neurotransmitter levels with ANS dysfunction in migraine. Here, ADCYAP1 is linked to migraine disorder.