The immunohistochemical analysis data exhibited that Caspase 3 was dramatically reduced in the solid tumors of mice with methylated PSMA3-AS1 or MIR22HG, whereas Ki67 was upregulated (Fig. 7F), implying that the methylation of lncRNAs promoted tumor growth by suppressing apoptosis in vivo. Here, CASP3 is linked to neoplasm.