‘Proton pump inhibitors (PPI) for uncomplicated peptic ulcer disease or erosive peptic oesophagitis at full therapeutic dosage for > 8 weeks’ was prevalent in around one quarter of patients (n = 75, 26.0%), followed by acetylcholinesterase inhibitors with concurrent treatment with drugs that reduce heart rate (n = 60, 21.0%), anticholinergics/antimuscarinics in patients with delirium or dementia (n = 28, 9.8%), and antimuscarinic drugs with dementia, or chronic cognitive impairment or narrow-angle glaucoma or chronic prostatism (n = 25, 8.7%). The gene discussed is ACHE; the disease is prostatitis.