Lrg1, which encodes a leucine-rich α-2-glycoprotein involved in IEC migration and wound healing42, was upregulated by most IECs during Cr infection but was most highly expressed in immature DCCs (pre-DCC and pro-DCC), suggesting that Lrg1 may have a role in the movement of DCCs up the crypts during Cr infection (Fig. 3c and Extended Data Figs. 2c, 5b,c and 6). This evidence concerns the gene DCC and infection.