Subsequent comparative pathway enrichment analysis against HALLMARK and REACTOME gene sets for most DMRs within gene-body regions revealed a significant enrichment across RHO GTPases, cell migration control, and leukemic stem cell maintenance (HSF1 activation) in BPDCN, whereas promotor regions in BPDCN compared to AML were methylated to a significantly higher degree in epigenetic and transcriptional regulation as well as TP53 regulation and cell cycle control. This evidence concerns the gene TP53 and acute myeloid leukemia.