GATA4 and coronary artery disorder: Through their work, Zuo et al. do a masterful job reinforcing the idea that there is a need for advanced sequencing to uncover novel genes and promoter regions of genes associated with CHD, including ToF.5 By continuing to uncover candidate genes, missing links in what is likely a complex multifactorial pathway with multiple gene-gene interactions underlying ToF can continue to be elucidated and, ultimately, lead to new therapeutic interventions in the clinical setting.