CENPA and cancer: These findings have direct clinical relevance as CENP-A is reported to be overexpressed in various cancer types, including prostate, ovarian, lung, breast, and gastric cancers, and its overexpression correlates with poor prognosis, disease stage, genomic instability, and altered response to therapeutic interventions (Ma et al, 2003; Qiu et al, 2013; Saha et al, 2020; Sun et al, 2016; Wu et al, 2012; Xu et al, 2020; Zhang et al, 2016).