FXN and Friedreich ataxia: While there are currently no curative treatments for the cardiac manifestations of FRDA, numerous therapeutic approaches are being tested in pre-clinical models9–11 As FRDA is a genetic disease caused by an autosomal recessive mutation in the frataxin gene (FXN) that encodes the highly conserved frataxin protein (FXN), genetic approaches for treatment are under investigation12–14.