ALDH2 and AMED syndrome, digenic: We have recently reported that a functional single-nucleotide polymorphism, ALDH2 rs671 (c.1510G>A, p.E504K), which is known to cause the Asian alcohol flushing phenotype, in combination with biallelic loss-of-function mutations in ADH5 leads to AMeDS, a digenic multisystem disorder10,11.