Our mouse model of AMeDS, harbouring double mutations (Adh5−/− and Aldh2-E506K, equivalent to the human ALDH2-E504K and hereafter called Aldh2KI) recapitulates the major clinical findings of AMeDS, such as short life span, growth failure and haematopoietic abnormalities (Extended Data Fig. 7a)11. The gene discussed is ALDH2; the disease is AMED syndrome, digenic.