In our animal model, lacking both aldehyde clearance metabolic processes (Adh5−/−Aldh2+/KI) and the TCR pathway (Csb−/−), symptoms of AMeDS are exacerbated by TCR deficiency; concurrently, symptoms of CS are highlighted due to aldehyde clearance deficiency. This evidence concerns the gene ADH5 and hyperinsulinemic hypoglycemia, familial, 4.