The cells of patients with AMeDS are hyper-sensitive to formaldehyde, and mice lacking both Adh5 and Aldh2 enzymatic activities show increased levels of formaldehyde in blood, indicating that the ADH5 and ALDH2 function to detoxify endogenous formaldehyde in a coordinated manner10,11. This evidence concerns the gene ALDH2 and AMED syndrome, digenic.