MAPT and Hypertension: Distinctive differential expression will be a vital component for any potential biomarker, and thus in addition to the SHR-SP model of hypertension comparison already reported22,47, the DEPs identified here should be compared with other CSVD models, including models of larger vessel CAA type-2 or a model prominently exhibiting Aβ plaque and tau AD pathologies. Additionally, follow up investigation of DEPs identified here for detection in biological fluids such as cerebrospinal fluid (CSF) and blood plasma will be necessary.