ACU intervention at the acupoints “Baihui,” “Dazhui,” “Shenshu,” and “Zusanli” improved cognitive function, especially learning and memory, by repairing synaptic damage in patients with cerebral ischemia, and exerted neuroprotective effects by modulating the expression of CREB, BDNF, BCL2, and BAX genes70,71. The gene discussed is BCL2; the disease is Cerebral ischemia.