ACU intervention at the acupoints “Baihui,” “Dazhui,” “Shenshu,” and “Zusanli” improved cognitive function, especially learning and memory, by repairing synaptic damage in patients with cerebral ischemia, and exerted neuroprotective effects by modulating the expression of CREB, BDNF, BCL2, and BAX genes70,71. This evidence concerns the gene BDNF and brain ischemia.