CLEC7A and obesity due to melanocortin 4 receptor deficiency: Beyond IVIGs, the loss of IgG sialic acid plays a mechanistic role in the development of obesity-induced hypertension, and supplementation of sialic acid reduces obesity-induced hypertension in mouse models13. (2) Galactose: galactose on IgG leads to anti-inflammatory cascades by facilitating the interaction between CD32b and dectin-1 in myeloid cells14.