TRAF2 and neoplasm: In a TNF-α-stimulated tumour cell in the inflammatory colorectal cancer microenvironment, upon binding of TNF-α to its receptor TNFR1, adaptor proteins TRADD and TRAF2 are recruited with cIAP-1 and/or cIAP-2 and RIP kinase [25–27] (Fig. 4E).